Abstract
N-Acetyl-S-farnesyl cysteine (AFC) is the minimal synthetic substrate for the enzyme Icmt, which methylates prenylated proteins. The desthio-AFC isostere 2 has been synthesized in racemic form. This analog was not an Icmt substrate, but instead a weak inhibitor with an IC50 of approximately 325 microM.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Cysteine / analogs & derivatives*
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Cysteine / chemical synthesis*
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Inhibitory Concentration 50
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Methyltransferases / antagonists & inhibitors
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Methyltransferases / metabolism
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Molecular Structure
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Sulfides / chemical synthesis*
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Sulfides / chemistry
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Terpenes / chemistry
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Terpenes / metabolism
Substances
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Sulfides
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Terpenes
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Methyltransferases
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Cysteine